CUTANEOUS BASOPHIL (JONES-MOTE) HYPERSENSITIVITY AFTER "TOLEROGENIC" DOSES OF INTRAVENOUS OVALBUMIN IN THE GUINEA PIG
نویسندگان
چکیده
منابع مشابه
Cutaneous Basophil (jones-mote) Hypersensitivity after "tolerogenic" Doses of Intravenous Ovalbumin in the Guinea Pig
Cutaneous basophil hypersensitivity (CBH) was studied for tolerogenic requirements. Graded doses of intravenous ovalbumin (OA) were given to guinea pigs which were subsequently immunized appropriately to produce CBH, classic delayed hypersensitivity (classic DH), and/or antibodies of both passive cutaneous anaphylaxis (PCA) and hemolytic types. Results showed that doses of intravenous antigen s...
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CBH to DNP-GL could be elicited only in responder guinea pigs which possess the genetic ability to develop classic delayed type hypersensitivity to DNP-PLL, the response to which is governed by the same gene. Since the defect in nonresponder animals seems to reside at the level of their T cells and not B cells, these results lend support to the contention that CBH, as well as DH, is dependent o...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1971
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.134.3.630